Novel Fully Customizable Topography CXL Applications for Refractive Corneal Changes
Narrative Responses:
Purpose
To evaluate the safety and efficacy of very high fluence, topography customized CXL (PiXL) treatments in myopic, and/or astigmatic refractive treatments.
Methods
12 cases subjected to PiXL procedure using excimer laser epithelail removal, 0.25% riboflavin solution soaking and 12Joules total UV energy applied for CXL. We evaluated pre-operatively and 1, 3, 6 months postoperatively for visual acuity, keratometry, cornea clarity and scatter, topography (Placido disc, Scheimpflug), as well as anterior segment OCT and endothelial cell changes.
Results
an average of 2.2 diopters of central corneal flattening were documented, with no endothelial or clarity changes. There was a slight regression of 1 diopter regression of the effect within the first month, that appeared stable thereafter.
Conclusion
The novel PiXL procedure appears safe and effective in significant myopic corrective changes without the need of corneal stroma tissue removal. Longer follow-up and further studies may be needed to refine the dose-effect nomogram and further validate these findings.