Use of Combined Biomechanical and Tomographic Data to Detect Keratoconus

Guilbert, Emmanuel

Use of Combined Biomechanical and Tomographic Data to Detect Keratoconus

Friday, April 25, 2014

KIOSKS (Boston Convention and Exhibition Center)

Emmanuel Guilbert, MD, Rothschild Foundation, Paris, France

Alain Saad, MD, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France

Alice Grise-Dulac, MD, Fondation Rothschild, Paris, France

Damien Gatinel, MD, Fondation Rothschild, Paris, France

Helene Rouger, Fondation Ophtalmologique Adolphe de Rothschild, PARIS, France

Marine Humeniuk, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France

Narrative Responses:

Purpose
To determine a new index using combined corneal biomechanical and tomographic data helping to detect keratoconus.

Methods
Data of 213 eyes separated into two groups were retrospectively reviewed : normal (n=109) and keratoconus (n=104). Corneal hysteresis (CH), corneal resistance factor (CRF) and other biomechanical parameters were measured with an ocular biomechanics analyzer. Corneal thickness was measured using a combined placido-scanning slit system.

Results
Using CH, CRF, H1, thinnest point and central corneal thickness, our index was able to discriminate normal cornea from keratoconus with a sensitivity of 96.2 % and a specificity of 90.8 %. ROC curve showed an area under curve of 0.967.

Conclusion
Sensitivity and specificity of our new index combining biomechanical and tomographic data were high in detecting keratoconus.