Evaluation of Posterior Corneal Change After Corneal Collagen CXL in Progressive Ectasia

Wakimasu, Koichi

Evaluation of Posterior Corneal Change After Corneal Collagen CXL in Progressive Ectasia

Friday, April 17, 2015

KIOSKS (San Diego Convention Center)

Koichi Wakimasu, MD

Osamu Hieda, MD

Shigeru Kinoshita, MD, PhD

Purpose
To evaluate the posterior corneal change after collagen cross-linking in patients with progressive ectasia.

Methods
This retrospective study involved 10 eyes of 9 patients with progressive ectasia that underwent riboflavin ultraviolet A collagen cross-linking using the standard (Dresden) protocol and that were followed-up for more than 2 years. Among those 10 eyes, 4 eyes did not wear a hard contact lens (HCL) (non-HCL group) and 6 eyes wore an HCL (HCL group) as a control after cross-linking. In both groups, keratometry and elevation of the posterior cornea at baseline and at 2-years post cross-linking were evaluated by corneal tomography (Pentacam^TM; OCULUS Optikgeräte GmbH, Wetzlar, Germany).

Results
There was no significant difference between the mean keratometry readings of the posterior cornea at baseline and at 2 years in both non-HCL group and HCL group. Mean elevation of the posterior cornea at the thinnest point was 106±25/90±7μm in the non-HCL group and 116±41/110±47μm in the HCL group. No significant change of elevation of the posterior cornea was found in both groups.

Conclusion
Regardless of whether or not an HCL was worn, the posterior surface of the cornea did not change, thus suggesting that ectasia did not progress post collagen cross-linking.