Macular Ganglion Cell Inner Plexiform Layer Thickness Profile Associated With Ocular Dominance
Purpose
To investigate of the characteristics of macula ganglion cell inner plexiform layer (GCIPL) thickness profiles associated with ocular dominance.
Methods
The study design is cross-sectional study. Both eyes of 199 participants with no ophthalmic abnormalities were imaged by spectral domain-optical coherence tomography (Cirrus HD-OCT, Carl Zeiss Meditec) and underwent dominant-eye testing using a hole-in-a-cared test (sighting dominance) at the same visit. Macular GCIPL as well as peripapillary RNFL thickness profiles in an individual were compared according to ocular dominance.
Results
Ocular dominance occurred predominantly in the right eye (right vs left: 72.36 vs. 27.60%; P<0.001). Dominant eyes had significantly thicker average, temporal, and nasal peripapillary RNFL thickness (P= 0.007, < 0.001 and 0.008), whereas non-dominant eyes had significantly thicker superior RNFL thickness compared to dominant eyes (P = 0.036). In the comparison of macular GCIPL thickness, dominant eyes accompanied significantly thicker average, inferonasal, and inferior sectors compared to non-dominant eyes (P = 0.040, .005, and 0.032). Ocular dominance was found to be only factor affecting average and inferior GCIPL thickness after adjusting for age, spherical equivalent, and ocular laterality (P= 0.023 and 0.024).
Conclusion
Dominant eyes accompanied significantly thicker average and inferior macula GCIPL. This is the first reported study demonstrating the macular GCIPL characteristics.