Difference in IOP-Lowering Effects of 3 Prostaglandin Analogs for Korean Glaucoma and Ocular Hypertension Patients
Purpose
To compare intraocular pressure(IOP) lowering effects of tafluprost, travoprost, bimatoprost respectively for Korean glaucoma patients.
Methods
All of 143 patients, 270 eyes, 203 eyes diagnosed with normal tension glaucoma(NTG), 8 eyes with ocular hypertension(OHT), 23 eyes with primary open-angle glaucoma(POAG), received 0.0015% tafluprost, 0.004% travoprost or 0.01% bimatoprost eye drops respectively once daily to compare and analyze the intraocular pressure gap of before, one week after, and one month after the treatment retrospectively.
Results
Tafluprost group, the average IOP was 15.94 ± 3.27 mmHg before treatment, 12.49 ± 2.48 mmHg after 1 week, and 12.51 ± 2.69 mmHg after 1 month. Travoprost group was 15.65 ± 3.06mmHg, 12.18 ± 2.96 mmHg and 12.89 ± 2.88 mmHg. Bimatoprost group was 17.04 ± 2.68 mmHg, 13.22 ± 2.56 mmHg and 13.91 ± 3.45 mmHg respectively. There was statistically significant reduction of IOP (p<0.0001). No significant relation in the bimatoprost group(p=0.298, r=0.171) in the baseline IOP and IOP reduction rate. However, the tafluprost group(p<0.0001, r=0.423) and travoprost group(p<0.0001, r=0.456), higher baseline IOP leaded to more IOP reduction.
Conclusion
Tafluprost, travoprost and bimatoprost are effective in short-term intraocular pressure reduction till one month after treatment. Bimatoprost showed significant intraocular pressure reduction regardless of baseline intraocular pressure, and as the baseline intraocular pressure was higher, the rate of intraocular pressure reduction was higher in tafluprost and travoprost group.