Ocular Surface Before and After Orbital Decompression: Prospective Trial

Monday, April 20, 2015: 1:36 PM
Room 1B (San Diego Convention Center)
Alexander Voldman, DO
Laura Gadzala, MD
Lee Wiley, MD
Tony Realini, MD
Jennifer Sivakcallcott, MD
John Nguyen, MD

To evaluate objective parameters of ocular surface status and to correlate with subjective symptoms in patients with Thyroid Eye Disease (TED) before and after orbital decompression.

Patients undergoing unilateral orbital decompression for TED are evaluated preoperatively and postoperatively with best corrected visual acuity (BCVA) and the following objective parameters of the ocular surface: Lissamine green staining, tear film breakup time (TBUT), Schirmer testing, and tear film osmolarity using the TearLab system.  In addition, patients fill out the Ocular Surface Disease Index (OSDI) questionnaire.

Ongoing study currently with preoperative data gathered from 7 eyes of 7 patients and postoperative data gathered from 2 patients. Follow-up ranges from 1 to 11 months.  Preliminary results show a statistically significant (p value < 0.001) improvement in the OSDI questionnaire scores (mean ± SD, Preop 41.17 ± 15.49, Postop 15.2  ± 0.94). When comparing the pre- and postoperative tear osmolarity, Schirmer testing, TBUT, and BCVA there was no statistically significant difference.

Preliminary analysis of this ongoing study suggest a potential benefit of decompression surgery on ocular surface status. The complete data set and analysis will be presented at the meeting.