Management of Persistent Corneal Graft Edema by Rho-Associated Kinase Inhibitors
Purpose
To report cases of corneal
persistent graft edema that was
successfully treated by Rhoassociated
kinase (ROCK) inhibitors.
Methods
Three eyes unresponsive to medical
treatment(BCVA ≤4/100)underwent
sub-conjunctival Fasudil injection
(0.5 mg/1 ml) 2 times with two
weeks interval time.
Results
Corneal clarity recovered and vision
improved 4-6 weeks after the
second injection. At three months,
vision improved to 20/160. Average
central corneal thickness was
579+/-10 μm, significantly lower
than its pretreatment value (744+/-9
μm).The average corneal
endothelial density in the central
cornea increased from 894 ± 64 to
1549.3 ± 98 cells/mm³.
Conclusion
These cases highlight
the possibility of the use of
subconjunctival ROCK inhibitors as
an alternative to regraft surgery for
certain forms of persistent corneal
graft edema.