Management of Persistent Corneal Graft Edema by Rho-Associated Kinase Inhibitors

Friday, April 17, 2015
KIOSKS (San Diego Convention Center)
Hamidreza Hasani, MD

Purpose
To report cases of corneal
persistent graft edema that was
successfully treated by Rhoassociated
kinase (ROCK) inhibitors.

Methods
Three eyes unresponsive to medical
treatment(BCVA ≤4/100)underwent
sub-conjunctival Fasudil injection
(0.5 mg/1 ml) 2 times with two
weeks interval time.

Results
Corneal clarity recovered and vision
improved 4-6 weeks after the
second injection. At three months,
vision improved to 20/160. Average
central corneal thickness was
579+/-10 μm, significantly lower
than its pretreatment value (744+/-9
μm).The average corneal
endothelial density in the central
cornea increased from 894 ± 64 to
1549.3 ± 98 cells/mm³.

Conclusion
These cases highlight
the possibility of the use of
subconjunctival ROCK inhibitors as
an alternative to regraft surgery for
certain forms of persistent corneal
graft edema.