Comparison of Corneal Biomechanical Properties in Patients With Psoriasis and Healthy Subjects
Purpose
To evaluate the differences in corneal biomechanical properties between healthy subjects and patients with psoriasis using the ocular response analyzer (ORA).
Methods
Fifty nine eyes of 59 psoriasis patients and 66 healthy individuals were included in the study. Corneal biomechanical parameters were obtained using ORA. Ultrasound pachymetry was used to measure central corneal thickness (CCT). The main parameters assessed were corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated pressure measurement (IOPg) and corneal-compensated intraocular pressure (IOPcc) via ORA. The dry eye evaluation was done with tear break up time (TBUT) and Shirmer test.
Results
The mean corneal hysteresis (CH) values in psoriasis and healthy subject eyes were 10.75 ±2.9 mmHg, 11.97 ±3,6 mmHg respectively.(p=0.047) The mean CRF values were 10.14 ±3.1 mmHg and 11.61 ±3,3 mmHg, respectively.(p=0.012) The mean CCT were 539,1 ±36μ and 536,3 ±28μ respectively.(p=0.643) Mean TBUT values were 8.2.±2.9 seconds(s) in psoriasis group and 10.4 ±3.6 s in healthy subject. (p <0.001) Mean Shirmer test values were less (8.9.±3.8 mm/5 min), in psoriasis than in healthy subjects (13.1 ±3.6 mm). (p < 0.001)
Conclusion
Psoriasis can influence the corneal biomechanical properties. The patients with psoriasis had lower CH and CRF, but higher IOPg and IOPcc values than healthy controls. These corneal biomechanical changes should be considered when determining IOP values.