Evaluation of in Vitro Glistening Formation in Different Hydrophobic Acrylic IOLs

Saturday, April 18, 2015: 1:19 PM
Room 5B (San Diego Convention Center)
Ramin Khoramnia, MD
Tamer Tandogan, MD
Florian T. Kretz, MD
Gerd U. Auffarth, MD

To compare the glistening formation in different hydrophobic acrylic intraocular lenses (IOLs).

Four hydrophobic IOL models of different manufacturers (AU6KA [Kowa, Japan], Envista [Bausch&Lomb, USA], Acrysof MA60AC [Alcon, USA], I-Sert PC-60AD [Hoya, Japan]) were analyzed. Glistenings were in an experimental setup created as aqueous-filled microvacuoles in five IOLs per model using an accelerated laboratory method. The IOLs were immersed in water at 45°C for 24 hours. The IOLs were then placed in a water bath with a temperature of 37°C for 2.5 hours to reduce the temperature. Images of the IOLs were taken with a camera attached to a microscope (90x magnification). The images were analyzed with an image analysis program (i-Solution, iMT Technology) for the comparison of glistening formation.

Glistenings were detectable in all lenses after the accelerated laboratory method. The range of the microvacuole density for the IOLs was as follows (in microvacuoles per square millimeter [MVs/mm²]): 1-2 (Envista [Bausch&Lomb, USA]), 1-4 (AU6KA [Kowa, Japan]), 507-804 (Acrysof MA60AC [Alcon, USA]), 684-2699 (I-Sert PC-60AD [Hoya, Japan]).

The amount of glistenings differed significantly between the examined IOLs. While two IOL models (AU6KA and Envista) only showed a glistening grade of 0 according to Miyata et al., the other two models (MA60AC and PC-60AD) showed a glistening grade of 3.