Comparison of 3 Designs of PCO-Preventing Rings

Saturday, April 18, 2015: 1:42 PM
Room 5B (San Diego Convention Center)
Guy Kleinmann, MD
Lee Slutzky

To investigate three designs of open capsule ring (OCR) with different size and density of side wall apertures on PCO and Sommering's ring formation.

Twenty-four NZW rabbits' eyes were divided to 3 groups. 3 different OCRs were implanted into the capsular bag after crystalline lens evacuation. Group A (n=8): 190 degrees of large side wall apertures, group B (n=9): 90 degrees of small side wall apertures, and group C (n=7): 175 degrees of small side wall apertures. The same intraocular lens was then implanted into the OCR.  A weekly slit lamp exam was performed for the 6 weeks of the study duration.  After 6 weeks the rabbits were scarified, the eyes were enucleated and fixated and then evaluated using the Miyake-Apple view and histology.

Similar low PCO levels and Sommering's ring formation were found in all the study groups. Six weeks slit lamp PCO level were: A: 0.4±0.7, B: 0.8±0.8, C: 0.5±0.8; p=0.5. Histology PCO level were: A: 0±0, B: 0.7±0.1, C: 0.4±1.1; p=0.25, Sommering's Ring area(%): A: 29+17, B: 26+12, C: 25+15; p=0.38. Area of Sommering's ring protrusion inside the OCR (%): A: 18+14, B:13+10, C: 16+13, P=0.31.

The three OCR designs showed similar PCO and Sommering's ring prevention. There seems to be a tendency for lower Sommering's ring protrusion inside the OCR in the low density small side wall apertures but the difference was not statistically significant.